Relevant News Links to Worldwide Problem of Antibiotic Resistant Infection
Current National and Health Security
DIBI Technology Publications
Anti-infective- Core to CPI Mission (path to human clinical trials)
Iron Sequestrant DIBI, a Potential Alternative for Nares Decolonization of Methicillin-Resistant Staphylococcus aureus, is Anti-infective and Inhibitory for Mupirocin-Resistant Isolates. Allan DS, Parquet MDC, Savage KA, Holbein BE. Antimicrob Agents Chemother 64:e02353-19.
Antibiotic resistant Acinetobacter baumannii is susceptible to the novel iron-sequestering anti-infective DIBI in vitro and in experimental pneumonia in mice. Parquet MDC, Savage KA, Allan DS, Ang MTC, Chen W, Logan SM, Holbein BE. Antimicrob Agents Chemother.
Novel Iron-Chelator DIBI Inhibits Staphylococcus aureus Growth
Suppresses Experimental MRSA Infection in Mice and Enhances the Activities of Diverse Antibiotics in vitro. Parquet MDC, Savage KA, Allan DS, Davidson RJ, Holbein BE. Front Microbiol.
Potential Mechanisms of Mucin-Enhanced Acinetobacter baumannii Virulence
in the Mouse Model of Intraperitoneal Infection. Harris G, Holbein BE, Zhou H, Xu HH, Chen W.
Infect Immun 87:e00591-19.
DIBI, a 3-hydroxypyridin-4-one chelator iron-binding polymer with enhanced antimicrobial activity.
Ang MTC, Gumbau-Brisa R, Allan DS, McDonald R, Ferguson MJ, Holbein BE, Bierenstiel M. Medchemcomm.
Exploiting the Achilles’ heel of iron dependence
in antibiotic resistant bacteria with new anti-microbial iron withdrawal agents. Holbein BE, Ang MTC, Allan DS, Chen W, Lehmann C. “Mitigation of Antimicrobial Resistance’’ Springer Nature (invited review, in press)
Collaborator-led Complementary studies (re platform aspects of CPI technology)
DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage Greenshields AL, Power Coombs MR, Fernando W, Holbein BE, Hoskin DW. Biometals
Anti-inflammatory effects of a novel iron chelator, DIBI, in experimental sepsis.
Thorburn T, Aali M, Kostek L, LeTourneau-Paci C, Colp P, Zhou J, Holbein B, Hoskin D, Lehmann C. Clin Hemorheol Microcirc.
The utility of iron chelators in the management of inflammatory disorders.
Lehmann C, Islam S, Jarosch S, Zhou J, Hoskin D, Greenshields A, Al-Banna N, Sharawy N, Sczcesniak A, Kelly M, Wafa K, Cheliak W, Holbein B.
Mediators Inflamm. 2015.
Inhibitory effect of iron withdrawal
by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells.
Power Coombs MR, Grant T, Greenshields AL, Arsenault DJ, Holbein BE, Hoskin DW. Exp Mol Pathol. 2015.